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These therapeutic effects and target engagement evidenced by reduced levels of NLRP3, ASC, cleaved caspase-1, IL-1 and IL-18 in the brain were confirmed in both a Parkinsons disease prevention model using -synuclein pre-formed fibrils and a therapeutic model initiated after symptom onset using PLP--synuclein transgenic mice

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Phase 3 trials are the key stage for FDA approval

ANZCA President Professor David Story noted near misses, last-minute cancellations, or worse, the risks of an immediate crisis and a long ICU stay, even mortality

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